pI: 6.2433 |
Length (AA): 938 |
MW (Da): 103193 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 8 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
57 | 470 | 5e84 (A) | 28 | 402 | 26.00 | 0.000000037 | 1 | 0.647965 | -0.08 |
58 | 806 | 4jne (A) | 3 | 604 | 27.00 | 0 | 1 | 0.791907 | 1.1 |
642 | 787 | 5cwg (A) | 71 | 196 | 34.00 | 0.47 | 0.9 | 0.39605 | -0.07 |
664 | 930 | 5j1i (A) | 1017 | 1294 | 25.00 | 0.13 | 1 | 0.514048 | -0.36 |
690 | 825 | 4tql (A) | 90 | 222 | 26.00 | 0.0061 | 0.22 | 0.393389 | -0.23 |
737 | 931 | 5cwk (A) | 4 | 170 | 33.00 | 0.17 | 0.93 | 0.423289 | -0.39 |
889 | 935 | 2maj (A) | 340 | 387 | 28.00 | 0 | 0.05 | 0.637607 | -3.81 |
889 | 937 | 4o9b (A) | 249 | 297 | 22.00 | 0 | 0.03 | 0.670739 | -4.53 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | VEG Tachyzoite. | Gregory |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | ME49 Tachyzoite, ME49 merozoite, ME49 Bradyzoite. | Gregory Hehl AB Sibley/Greg |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | ME49 Oocyst. | Fritz HM |
Sibley/Greg | ToxoDB |
Gregory | ToxoDB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Ortholog group members (OG5_128359)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G16660 | heat shock protein 70 |
Babesia bovis | BBOV_I003640 | DnaK family domain containing protein |
Brugia malayi | Bm1_39345 | dnaK protein |
Candida albicans | CaO19.5830 | translocation of protein precursors across ER |
Candida albicans | CaO19.13252 | translocation of protein precursors across ER |
Caenorhabditis elegans | CELE_T14G8.3 | Protein T14G8.3, isoform A |
Caenorhabditis elegans | CELE_T24H7.2 | Protein T24H7.2 |
Cryptosporidium hominis | Chro.20349 | HSP protein |
Cryptosporidium parvum | cgd2_3330 | APG-1 like HSP70 domain containing protein, signal peptide plus likely ER retention motif |
Dictyostelium discoideum | DDB_G0273093 | heat shock protein 70 family member |
Dictyostelium discoideum | DDB_G0273813 | heat shock protein 70 family member |
Drosophila melanogaster | Dmel_CG2918 | CG2918 gene product from transcript CG2918-RB |
Echinococcus granulosus | EgrG_000981800 | Heat shock protein Hsp70 |
Entamoeba histolytica | EHI_148990 | heat shock protein 70, putative |
Echinococcus multilocularis | EmuJ_000981800 | Heat shock protein Hsp70 |
Homo sapiens | ENSG00000149428 | hypoxia up-regulated 1 |
Leishmania braziliensis | LbrM.34.4680 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_354780.1 | Hsp70 protein, putative |
Leishmania infantum | LinJ.35.4780 | hypothetical protein, conserved |
Leishmania major | LmjF.35.4710 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.34.4710 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_02797 | dnaK protein |
Mus musculus | ENSMUSG00000032115 | hypoxia up-regulated 1 |
Neospora caninum | NCLIV_046170 | Heat Shock Protein 70, ER lumen, related |
Oryza sativa | 4330492 | Os02g0710900 |
Plasmodium berghei | PBANKA_1357200 | heat shock protein 110, putative |
Plasmodium falciparum | PF3D7_1344200 | heat shock protein 110, putative |
Plasmodium knowlesi | PKNH_1257200 | heat shock protein 110, putative |
Plasmodium vivax | PVX_083105 | heat shock protein 110, putative |
Plasmodium yoelii | PY05402 | putative HSP protein |
Saccharomyces cerevisiae | YKL073W | Hsp70 family chaperone LHS1 |
Schistosoma japonicum | Sjp_0060680 | ko:K09486 hypoxia up-regulated 1, putative |
Schistosoma mansoni | Smp_088950 | hypothetical protein |
Schmidtea mediterranea | mk4.000709.08 | Hypoxia up-regulated protein 1 |
Schmidtea mediterranea | mk4.000785.07 | Hypoxia up-regulated protein 1 |
Trypanosoma brucei gambiense | Tbg972.9.5670 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.9.9860 | 170 kDa glucose-regulated protein, putative |
Trypanosoma cruzi | TcCLB.508457.20 | Hsp70 protein, putative |
Trypanosoma cruzi | TcCLB.506885.440 | Hsp70 protein, putative |
Toxoplasma gondii | TGME49_226830 | DnaK family protein |
Theileria parva | TP01_0479 | dnaK domain protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.211.1390 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb09.211.1390 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb09.211.1390 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb09.211.1390 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1357200 | Plasmodium berghei | Essential | plasmo |
TGME49_226830 this record | Toxoplasma gondii | Probably essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.